the 216+ II has:
- Intel 64Bit architecture
- More powerful
- and a few other SW-Synology features

But if you only need the standard apps from Synology and want to stream video (4K), or run photo albums, file management, then the 216play is also sufficient. The 216+II is more for demanding users who, for example, want to manage several files at the same time or have several simultaneous accesses (the 216play can also do this, but with less performance), etc.