Hello!
So technically the card fits into the slots in any case (you can also put it into the "big" PCI slots, that's how I have it). I am now running it under Windows 10 and it would be very untypical if it did not run on Windows 11. It doesn't say anything on the TP Link manufacturer's page either, but one if it says Win10 compatible, then that also applies to Win11.
I didn't have to install any special drivers, Windows does it all by itself. Installed, booted up, finished.

I installed it on an MB x99 and it works, no reason why it shouldn't.

Hello zwirulose

My Windows 11 runs really great, however I would highly recommend you install the latest drivers from ASUS. I have found that this can improve performance significantly. Especially with your motherboard, this shouldn't cause any problems as it supports all versions of PCI Express. By updating the drivers, you can ensure that your system runs smoothly and at its best, and may even enjoy some additional benefits in terms of speed and stability.

hello ... running top..