I operate two devices on this monitor and use the PnP function. With Picture-by-Picture you can operate two different devices on the monitor at the same time, whereby the monitor displays one input source on the left half and the second input source on the right half of the monitor.
So you can either
a) connect two devices to the monitor at the same time and also operate/use them or
b) use only one device at a time and use the entire screen for it.

Unfortunately, I can't say whether it just works like that, I didn't find it when I tried it out. However, at the time of the initial installation, I plugged it in via an HDMI and it pulled up the whole picture for me, so it's better to use only one side for a device. Basically, there are 2 Full HD screens next to each other. Therefore, I would answer your question with a no.