When the USA becomes the target and the clock is ticking, it falls to one man to save the lives of millions. The US military has stationed troops in over 150 countries worldwide. For a group of rogue states, this is unacceptable, and a terrible ultimatum called The Blacklist is issued. A deadly countdown of terrorist attacks against key US interests. With no end in sight and no action plan, the US government must deploy one of its strongest weapons - Sam Fisher.

As the leader of the newly formed Fourth Echelon unit, a secret unit that answers solely to the President of the United States, Sam and his team must hunt down these terrorists by any means necessary and stop the countdown on the Blacklist before it reaches zero.