The main difference between Ergo M575s and Ergo M575 (without s) is the wireless connection and the battery supply. The Ergo M575s uses Bluetooth and USB with an AA battery that lasts up to 18 months and has a compartment to store the Logi Bolt adapter. The Ergo M575 (without s) also offers Bluetooth, but has no dedicated adapter storage and uses a different power supply. In addition, the Ergo M575s has 5 buttons, while the MX Ergo S (a different model) has more buttons and additional functions that are missing on the M575.

Other differences are:
- The Ergo M575s is lighter (145 g) than the MX Ergo S (259 g).
- The Ergo M575s has a plastic construction, while the MX Ergo S has a rubberised surface.
- The Ergo M575s does not have a switch function between Bluetooth and Logi Bolt, whereas the MX Ergo S does.

The differences between the Ergo M575s and the original Ergo M575 (without s) are mainly to be seen in the improved battery, adapter storage and connectivity of the M575s. The M575 (without s) also has a maximum resolution of 2000 dpi and supports Bluetooth, but no explicit adapter storage.