The main difference between the two products lies in the functions and features. Here are some of the most important differences:

- Form factor and size: The TUF GAMING B650-E WIFI is an ATX board, while the TUF GAMING B650-PLUS WIFI is also ATX, but may offer fewer connectivity options.
- RAM speed: Both support similar RAM speeds, but the TUF GAMING B650-E WIFI might offer slightly higher transfer rates.
- Connectivity: The TUF GAMING B650-E WIFI may offer more USB ports and other connectivity options such as USB 20Gbps.
- Cooling and fans: The TUF GAMING B650-E WIFI could offer more fan ports for better cooling.