The main difference between the Poly SYNC 40 SY40-M Speakerphone and the Poly Sync 40 lies in the following aspects:

- Model variant: the Poly SYNC 40 SY40-M is specifically optimised for Microsoft environments, while the Poly Sync 40 is a more general version that is compatible with various platforms.
- Software integration: The SY40-M model offers tight integration with Microsoft Teams and other Microsoft tools, enabling a seamless experience in Microsoft environments. The Standard model, on the other hand, supports a wider range of conferencing software solutions.
- Price: The price may vary by dealer and region, but the SY40-M model is often priced similarly or slightly higher than the standard version, due to the specific Microsoft integration.

These differences make the Poly SYNC 40 SY40-M particularly suitable for organisations that work heavily in Microsoft ecosystems.