Yes, is listed as compatible in the following link:
https://www.asus.com/de... However, the BIOS of the ASUS PRIME B350-PLUS must be at least version 3803.
Small hint: A BIOS update can only be carried out with a running system. Therefore, if the motherboard comes with an older BIOS version than 3803, you must first install another compatible processor so that you can update the BIOS - only after the BIOS update can you use the Ryzen 5 2600X.
Why not just buy a B450 motherboard? The B350s came out with the Ryzen 1XXX, the B450 boards are more for the Ryzen 2XXX series. I have a Gigabyte B450 Aorus Pro
Gigabyte B450 Aorus Pro (AM4, AMD B450, ATX) with the Ryzen 5 2600X in use, but it currently has somewhat longer delivery times.