I use P3D4. Saitek drivers worked as long as you used a 32 bit simulator. Logitech software does not work for me. I bought SPAD.next especially for my two panels. Everything can be programmed with it, if the aircraft developers allow it. There are also ready-made profiles, but not everything. There is X-Plane support in this software. That means you can work with it.
So in a nutshell everything is a bit uncertain and you also have to pay for extra software. Maybe the Logitech software will work for you. Check out what they say about compatibility with X-Plane.