In general, it is compatible, it is validated since BIOS version 1004.
and more detailed information on CPU compatibility is available on the following page https://rog.asus.com/motherboar....

I ordered this motherboard a while ago with a 5900x, it is compatible without any problem.
This motherboard can also be used under Windows 11, you will need to change the following setting in the Bios:
check Advanced > AMD fTPM Configuration > TPM Device Selection and make sure it's set to Firmware TPM (assuming you don't have a distinct TPM chip installed).