The motherboard is compatible with graphics cards using a standard PCIe interface, such as the RTX 5090. There are no known specific restrictions preventing the use of an RTX 5090 with this motherboard. However, compatibility mainly depends on the available PCIe slot (usually PCIe x16) and the right power supply for the graphics card. This MSI MAG B650 TOMAHAWK WIFI motherboard has an ATX format with compatible PCIe slots, which means that an RTX 5090 can be installed, although it is advisable to check that the power supply and case support the size and power consumption of the RTX 5090.