You can pair the R2 with an Apple TV, the direction and back buttons work, but no other secondary functions: no volume, no control centre, no Siri... so it's impossible to adjust the language or subtitles during playback.
It's not a first choice for an Apple TV, but if you need it for something else and want to use it with the Apple TV as well, why not.

Hello,
I use the remote control with a Mac Mini, via youtube and Vlc, and it works very well.

Massimo Bonomo.