The main differences between the MX Keys Combo for Business Gen 2 and the Gen 1 are as follows:

## Mouse Model
- The Gen 1 includes the MX Master 3 mouse, while the Gen 2 includes the MX Master 3S mouse.

## Mouse DPI
- The MX Master 3S in the Gen 2 has an 8,000 DPI optical sensor, which is an upgrade from the 4,000 DPI of the MX Master 3 in the Gen 1.

## Mouse Features
- The MX Master 3S in the Gen 2 features Quiet Click technology, which reduces click noise by 90%, and it also includes the MagSpeed™ wheel for faster and more precise scrolling.

These changes enhance the performance, precision, and comfort of the Gen 2 combo compared to the Gen 1.