The layout of the "Asus ROG Strix Scope II 96 Wireless Keyboard" cannot be changed in the traditional sense, but it does offer some specific customisations. The keyboard keeps the 96% layout, which includes all functions and number keys in a compact form, but does not allow the layout of the keys to be changed.

However, there are some customisation features available:
- You can record macros on-the-fly and map them to fully programmable keys.
- You can configure hotkeys and other functions using the function key.
- The keyboard supports hot-swap of mechanical switches, allowing you to replace switches with other types of mechanical switches.

These options allow you to customise the keyboard experience, even if the physical layout of the keys remains fixed.