The 435 Wireless Mouse Multi-Device (Wireless) from HP cannot directly replace a defective mouse from an HP wireless keyboard/mouse set, as it is connected with its own USB-A nano dongle or Bluetooth 5.0 and is not specifically designed as a replacement for a set. The connection is made via its own receiver or Bluetooth, which is not necessarily compatible with the set's receiver. For a seamless replacement function, the replacement mouse should belong exactly to the set or be compatible with its receiver. The 435 Wireless Mouse is a stand-alone, multi-device capable mouse with programmable buttons and ergonomic design, designed to work with up to two devices.