The drive can be connected to an old Mac with USB2.0, but is then also slower (because of USB2.0).
The disadvantage of the drive compared to a 3.5'' drive is that it is less stable in continuous operation due to its compact design. So if you want the drive to run continuously for several weeks (as a NAS, so to speak), you should probably go for a 3.5'' solution with its own power supply. If you only need it temporarily and want something light to take along, then it is reliable enough. I have not had any bad experiences so far