America, 1899. The end of the Wild West era has arrived, and lawmen are hunting down the last remaining outlaw gangs. Those who resist and do not surrender will be killed.

After a botched robbery in the town of Blackwater, Arthur Morgan and the Van der Linde gang are on the run. With federal agents and the best bounty hunters in the country hot on their heels, the gang must carve a path through the unforgiving heart of America by robbing, stealing, and fighting to survive. As increasing internal conflicts threaten to tear the gang apart, Arthur must choose between his own ideals and his loyalty to the gang he once grew up with.